InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MOV10

Summary

InnateDB Protein

IDBP-686792.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MOV10

Protein Name

Putative helicase MOV-10

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000018997

InnateDB Gene

IDBG-634975 (MOV10)

Protein Structure

UniProt Annotation

Function

Probable RNA helicase. Required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA- mediated cleavage of complementary mRNAs by RISC (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, P-body {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.

Predicted by orthology
Total	48 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0031047	gene silencing by RNA
GO:0035279	mRNA cleavage involved in gene silencing by miRNA

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005615	extracellular space
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR006935 Helicase/UvrB domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF04851

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q0V8H6

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

523206

UniGene

Bt.2939

RefSeq

NP_001069307

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC148151 BT026242

GenPept

AAI48152 ABG67081