InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SND1

Summary

InnateDB Protein

IDBP-686794.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SND1

Protein Name

Staphylococcal nuclease domain-containing protein 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000014154

InnateDB Gene

IDBG-634983 (SND1)

Protein Structure

UniProt Annotation

Function

Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Plays a role in cell viability. Functions as a transcriptional coactivator for STAT5. Plays a role in cell viability (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Melanosome {ECO:0000250}. Note=In IL-4 stimulated cells colocalizes with STAT6 in the nucleus. {ECO:0000250}.

Disease Associations

Tissue Specificity

In lactating cows highly expressed in mammary epithelial cells. {ECO:0000269PubMed:11691653}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 49 interaction(s) predicted by orthology.

Predicted by orthology
Total	49 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004518	nuclease activity
GO:0005515	protein binding
GO:0016788	hydrolase activity, acting on ester bonds
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0031047	gene silencing by RNA
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0016020	membrane
GO:0016442	RISC complex
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome
GO:0097433	dense body

Protein Structure and Domains

PDB ID

InterPro

IPR002999 Tudor domain
IPR016071 Staphylococcal nuclease (SNase-like), OB-fold
IPR016685 RNA-induced silencing complex, nuclease component Tudor-SN

PFAM

PF00567
PF00565

PRINTS

PIRSF

PIRSF017179

SMART

SM00333
SM00318

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q863B3

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

404098

UniGene

Bt.61314

RefSeq

NP_991353

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AY273893 BC104504

GenPept

AAI04505 AAP31682