InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: BT.26959

Summary

InnateDB Protein

IDBP-686903.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.26959

Protein Name

mevalonate kinase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000006828

InnateDB Gene

IDBG-635086 (BT.26959)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004496	mevalonate kinase activity
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0042802	identical protein binding

Biological Process

GO:0006695	cholesterol biosynthetic process
GO:0008152	metabolic process
GO:0008299	isoprenoid biosynthetic process
GO:0016310	phosphorylation
GO:0050728	negative regulation of inflammatory response

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001174 Galactokinase/homoserine kinase
IPR006204 GHMP kinase N-terminal domain
IPR006205 Mevalonate kinase
IPR006206 Mevalonate/galactokinase
IPR013750 GHMP kinase, C-terminal domain
IPR020568 Ribosomal protein S5 domain 2-type fold

PFAM

PF00288
PF08544

PRINTS

PR00960
PR00959

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite