Version 5.4
Bos taurus Protein: DCTN2
Summary
InnateDB Protein IDBP-686954.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DCTN2
Protein Name Dynactin subunit 2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000014053
InnateDB Gene IDBG-635139 (DCTN2)
Protein Structure
UniProt Annotation
Function Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.
Predicted by orthology
Total 45 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003774 motor activity
GO:0005515 protein binding
GO:0030507 spectrin binding
Biological Process
GO:0007017 microtubule-based process
GO:0007052 mitotic spindle organization
GO:0007067 mitotic nuclear division
GO:0008152 metabolic process
GO:0008283 cell proliferation
GO:0032402 melanosome transport
Cellular Component
GO:0000776 kinetochore
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005856 cytoskeleton
GO:0005869 dynactin complex
GO:0005874 microtubule
GO:0016020 membrane
GO:0030286 dynein complex
GO:0030426 growth cone
GO:0031982 vesicle
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3ZCF0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 527201
UniGene Bt.16534
RefSeq NP_001029730
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102441
GenPept AAI02442

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca