Version 5.4
Bos taurus Protein: FAAP24
Summary
InnateDB Protein IDBP-686969.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FAAP24
Protein Name Fanconi anemia-associated protein of 24 kDa
Synonyms FAAP24;
Species Bos taurus
Ensembl Protein ENSBTAP00000013731
InnateDB Gene IDBG-635138 (FAAP24)
Protein Structure
UniProt Annotation
Function Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
Biological Process
GO:0006281 DNA repair
GO:0006974 cellular response to DNA damage stimulus
Cellular Component
GO:0005634 nucleus
GO:0043240 Fanconi anaemia nuclear complex
Protein Structure and Domains
PDB ID
InterPro IPR010994 RuvA domain 2-like
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2KHY5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 510793
UniGene Bt.9213
RefSeq NP_001039527
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC112837
GenPept AAI12838

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca