Version 5.4
Bos taurus Protein: CD53
Summary
InnateDB Protein IDBP-687008.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD53
Protein Name Leukocyte surface antigen CD53
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000008479
InnateDB Gene IDBG-635180 (CD53)
Protein Structure
UniProt Annotation
Function Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}. Cell junction {ECO:0000250}. Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Concentrates in localized microdomains along the plasma membrane at the contact sites between cells of fused myotubes. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:1901741 positive regulation of myoblast fusion
Cellular Component
GO:0001772 immunological synapse
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000301 Tetraspanin
IPR008952 Tetraspanin, EC2 domain
IPR018499 Tetraspanin/Peripherin
PFAM PF00335
PRINTS PR00259
PIRSF PIRSF002419
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q58DM3
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 505040
UniGene Bt.14005
RefSeq NP_001029404
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC113322 BT021574
GenPept AAI13323 AAX46421

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca