InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PKD1

Summary

InnateDB Protein

IDBP-687064.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PKD1

Protein Name

polycystic kidney disease 1 (autosomal dominant)

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000027480

InnateDB Gene

IDBG-635133 (PKD1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0019904	protein domain specific binding
GO:0030246	carbohydrate binding
GO:0044325	ion channel binding

Biological Process

GO:0001502	cartilage condensation
GO:0001568	blood vessel development
GO:0001701	in utero embryonic development
GO:0001822	kidney development
GO:0001889	liver development
GO:0001892	embryonic placenta development
GO:0006611	protein export from nucleus
GO:0006807	nitrogen compound metabolic process
GO:0006816	calcium ion transport
GO:0007050	cell cycle arrest
GO:0007218	neuropeptide signaling pathway
GO:0007259	JAK-STAT cascade
GO:0007507	heart development
GO:0016337	single organismal cell-cell adhesion
GO:0018105	peptidyl-serine phosphorylation
GO:0021510	spinal cord development
GO:0021915	neural tube development
GO:0031659	positive regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0032092	positive regulation of protein binding
GO:0034405	response to fluid shear stress
GO:0042994	cytoplasmic sequestering of transcription factor
GO:0043588	skin development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048565	digestive tract development
GO:0048754	branching morphogenesis of an epithelial tube
GO:0048806	genitalia development
GO:0050982	detection of mechanical stimulus
GO:0051216	cartilage development
GO:0060236	regulation of mitotic spindle organization
GO:0060428	lung epithelium development
GO:0060674	placenta blood vessel development
GO:0061136	regulation of proteasomal protein catabolic process
GO:0070588	calcium ion transmembrane transport
GO:0072001	renal system development
GO:0072164	mesonephric tubule development
GO:0072177	mesonephric duct development
GO:0072205	metanephric collecting duct development
GO:0072218	metanephric ascending thin limb development
GO:0072237	metanephric proximal tubule development
GO:0072287	metanephric distal tubule morphogenesis

Cellular Component

GO:0002133	polycystin complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005929	cilium
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0031512	motile primary cilium
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000203 GPS motif
IPR000372 Leucine-rich repeat-containing N-terminal
IPR000434 Polycystic kidney disease type 1 protein
IPR000483 Cysteine-rich flanking region, C-terminal
IPR000601 PKD domain
IPR001024 PLAT/LH2 domain
IPR001304 C-type lectin
IPR002859 PKD/REJ-like protein
IPR002889 Carbohydrate-binding WSC
IPR003591 Leucine-rich repeat, typical subtype
IPR006228 Polycystin cation channel
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR013122 Polycystin cation channel, PKD1/PKD2
IPR013994 Carbohydrate-binding WSC, subgroup
IPR014010 Egg jelly receptor, REJ-like
IPR016187 C-type lectin fold
IPR022409 PKD/Chitinase domain

PFAM