Version 5.4
Bos taurus Protein: APOPT1
Summary
InnateDB Protein IDBP-687305.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APOPT1
Protein Name UPF0671 protein C14orf153 homolog
Synonyms APOP-1; C14orf153; C21H14orf153;
Species Bos taurus
Ensembl Protein ENSBTAP00000028246
InnateDB Gene IDBG-635467 (APOPT1)
Protein Structure
UniProt Annotation
Function Plays a role in the regulation of apoptosis. Mediates mitochondria-induced cell death in vascular smooth muscle cells through the release of cytochrome c from mitochondria, followed by the activation of the caspase cascade (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006915 apoptotic process
GO:0034393 positive regulation of smooth muscle cell apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0097193 intrinsic apoptotic signaling pathway
Cellular Component
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID
InterPro IPR018796 Uncharacterised protein family UPF0671
PFAM PF10231
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q148E1
PhosphoSite PhosphoSite-
TrEMBL Q1JPB8
UniProt Splice Variant
Entrez Gene 617441
UniGene
RefSeq NP_001069927
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC118424 BT025435
GenPept AAI18425 ABF57391

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca