Version 5.4
Bos taurus Protein: PSRC1
Summary
InnateDB Protein IDBP-687323.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PSRC1
Protein Name Proline/serine-rich coiled-coil protein 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000025034
InnateDB Gene IDBG-635484 (PSRC1)
Protein Structure
UniProt Annotation
Function Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Note=Detected at the mitotic spindle and spindle poles. Diffusely distributed throughout the cell during interphase (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
Biological Process
GO:0001578 microtubule bundle formation
GO:0007049 cell cycle
GO:0007067 mitotic nuclear division
GO:0007080 mitotic metaphase plate congression
GO:0009987 cellular process
GO:0030308 negative regulation of cell growth
GO:0031116 positive regulation of microtubule polymerization
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0051301 cell division
GO:0060236 regulation of mitotic spindle organization
Cellular Component
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005876 spindle microtubule
GO:0015630 microtubule cytoskeleton
GO:0030496 midbody
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q29RJ9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 541250
UniGene Bt.58479
RefSeq NP_001039966
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC114140
GenPept AAI14141

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca