Version 5.4
| Bos taurus Protein: ISG15 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Protein | IDBP-687402.2 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | ISG15 | ||||||||||||||||||
| Protein Name | Ubiquitin-like protein ISG15 | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Bos taurus | ||||||||||||||||||
| Ensembl Protein | ENSBTAP00000019573 | ||||||||||||||||||
| InnateDB Gene | IDBG-635562 (ISG15) | ||||||||||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||||||||||
| Function | Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. ISGylation involves a cascade of enzymatic reactions involving E1, E2, and E3 enzymes which catalyze the conjugation of ISG15 to a lysine residue in the target protein. Exhibits antiviral activity towards both DNA and RNA viruses. The secreted form of ISG15 can: induce natural killer cell proliferation, augment lymphokine-activated-killer (LAK) activity, induce dendritic cell maturation, act as a chemotactic factor for neutrophils and act as a IFN-gamma-inducing cytokine playing an essential role in antimycobacterial immunity (By similarity). In response to IFN-tau secreted by the conceptus, may ligate to and regulate proteins involved in the release of prostaglandin F2-alpha (PGF), and thus prevent lysis of the corpus luteum and maintain the pregnancy. {ECO:0000250, ECO:0000269PubMed:9546718}. | ||||||||||||||||||
| Subcellular Localization | Cytoplasm. Secreted {ECO:0000250}. Note=Exists in three distinct states: free within the cell, released into the extracellular space, or conjugated to target proteins. {ECO:0000250}. | ||||||||||||||||||
| Disease Associations | |||||||||||||||||||
| Tissue Specificity | Expressed in endometrium and uterine flushings of pregnant cow. Also secreted. Not detected in spleen, liver, corpus luteum or muscle. {ECO:0000269PubMed:10406469, ECO:0000269PubMed:9348245}. | ||||||||||||||||||
| Comments | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 177 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||||||||||
| PDB ID | |||||||||||||||||||
| InterPro |
IPR000626
Ubiquitin-like IPR019956 Ubiquitin IPR022617 Rad60/SUMO-like domain IPR029071 Ubiquitin-related domain |
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| PFAM |
PF00240
PF14560 PF11976 |
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| PRINTS |
PR00348
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| PIRSF | |||||||||||||||||||
| SMART |
SM00213
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| TIGRFAMs | |||||||||||||||||||
| Post-translational Modifications | |||||||||||||||||||
| Modification | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | O02741 | ||||||||||||||||||
| PhosphoSite | PhosphoSite- | ||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 281871 | ||||||||||||||||||
| UniGene | |||||||||||||||||||
| RefSeq | NP_776791 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | |||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AF069133 BC102318 U96014 | ||||||||||||||||||
| GenPept | AAB57687 AAD56716 AAI02319 | ||||||||||||||||||