Version 5.4
Bos taurus Protein: NOC2L
Summary
InnateDB Protein IDBP-687457.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NOC2L
Protein Name Nucleolar complex protein 2 homolog
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000021980
InnateDB Gene IDBG-635603 (NOC2L)
Protein Structure
UniProt Annotation
Function Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus, nucleoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Translocates from the nucleoli to the nucleoplasm in presence of several stressors like ultraviolet irradiation and actinomycin-D. Predominantly detected in the nucleoli in non-mitotic cells. Predominantly detected in nucleoplasma in cells undergoing mitosis (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0003714 transcription corepressor activity
GO:0005488 binding
GO:0005515 protein binding
GO:0031491 nucleosome binding
GO:0042393 histone binding
GO:0044822 poly(A) RNA binding
GO:0070491 repressing transcription factor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002903 negative regulation of B cell apoptotic process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006915 apoptotic process
GO:0031497 chromatin assembly
GO:0032066 nucleolus to nucleoplasm transport
GO:0034644 cellular response to UV
GO:0035067 negative regulation of histone acetylation
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
Protein Structure and Domains
PDB ID
InterPro IPR005343 Nucleolar complex protein 2
IPR016024 Armadillo-type fold
PFAM PF03715
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3SYU1
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 508638
UniGene Bt.47767
RefSeq NP_001029498
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC103386
GenPept AAI03387

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca