Version 5.4
Bos taurus Protein: C1D
Summary
InnateDB Protein IDBP-687508.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C1D
Protein Name Nuclear nucleic acid-binding protein C1D
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000006000
InnateDB Gene IDBG-635663 (C1D)
Protein Structure
UniProt Annotation
Function Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=EXOSC10 is required for nucleolar localization. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003714 transcription corepressor activity
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0016922 ligand-dependent nuclear receptor binding
Biological Process
GO:0000460 maturation of 5.8S rRNA
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006364 rRNA processing
GO:0006915 apoptotic process
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0017053 transcriptional repressor complex
Protein Structure and Domains
PDB ID
InterPro IPR007146 Sas10/Utp3/C1D
PFAM PF04000
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q32PE4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 506667
UniGene
RefSeq NP_001032525
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC108147
GenPept AAI08148

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca