InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: AURKB

Summary

InnateDB Protein

IDBP-687509.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AURKB

Protein Name

serine/threonine-protein kinase 12

Synonyms

AIM-1; ARK-2; STK-1; STK12;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000002250

InnateDB Gene

IDBG-635657 (AURKB)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 74 interaction(s) predicted by orthology.

Predicted by orthology
Total	74 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0035174	histone serine kinase activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002903	negative regulation of B cell apoptotic process
GO:0006468	protein phosphorylation
GO:0007067	mitotic nuclear division
GO:0016310	phosphorylation
GO:0031577	spindle checkpoint
GO:0032091	negative regulation of protein binding
GO:0032467	positive regulation of cytokinesis
GO:0034501	protein localization to kinetochore
GO:0034644	cellular response to UV
GO:0036089	cleavage furrow formation
GO:0043146	spindle stabilization
GO:0043988	histone H3-S28 phosphorylation
GO:0051256	spindle midzone assembly involved in mitosis

Cellular Component

GO:0000779	condensed chromosome, centromeric region
GO:0000780	condensed nuclear chromosome, centromeric region
GO:0005634	nucleus
GO:0010369	chromocenter
GO:0030496	midbody
GO:0032133	chromosome passenger complex
GO:0045171	intercellular bridge

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q08DN4

UniProt Splice Variant

Entrez Gene

360192

UniGene

Bt.7331

RefSeq

NP_898907

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC123650 DAAA02048813

GenPept

AAI23651