InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MAP3K4

Summary

InnateDB Protein

IDBP-687560.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP3K4

Protein Name

mitogen-activated protein kinase kinase kinase 4

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000026753

InnateDB Gene

IDBG-635619 (MAP3K4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000186	activation of MAPKK activity
GO:0001890	placenta development
GO:0006468	protein phosphorylation
GO:0010225	response to UV-C
GO:0010468	regulation of gene expression
GO:0019100	male germ-line sex determination
GO:0035556	intracellular signal transduction
GO:0043507	positive regulation of JUN kinase activity
GO:0060718	chorionic trophoblast cell differentiation
GO:1900745	positive regulation of p38MAPK cascade

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt