Version 5.4
Bos taurus Protein: APTX
Summary
InnateDB Protein IDBP-687575.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APTX
Protein Name aprataxin
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000042890
InnateDB Gene IDBG-635714 (APTX)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003684 damaged DNA binding
GO:0003690 double-stranded DNA binding
GO:0003725 double-stranded RNA binding
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0008967 phosphoglycolate phosphatase activity
GO:0033699 DNA 5'-adenosine monophosphate hydrolase activity
GO:0046403 polynucleotide 3'-phosphatase activity
GO:0046872 metal ion binding
GO:0047485 protein N-terminus binding
GO:0051219 phosphoprotein binding
Biological Process
GO:0000012 single strand break repair
GO:0000738 DNA catabolic process, exonucleolytic
GO:0006266 DNA ligation
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006974 cellular response to DNA damage stimulus
GO:0016311 dephosphorylation
GO:0031647 regulation of protein stability
GO:0042542 response to hydrogen peroxide
GO:0098506 polynucleotide 3' dephosphorylation
Cellular Component
GO:0000785 chromatin
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
Protein Structure and Domains
PDB ID
InterPro IPR001310 Histidine triad (HIT) protein
IPR008984 SMAD/FHA domain
IPR011146 HIT-like domain
PFAM PF01230
PRINTS PR00332
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F1MVI2
UniProt Splice Variant
Entrez Gene 359714
UniGene Bt.16472
RefSeq NP_872595
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02023851
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca