Version 5.4
Bos taurus Protein: SOX4
Summary
InnateDB Protein IDBP-687674.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOX4
Protein Name SRY (sex determining region Y)-box 4
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000054654
InnateDB Gene IDBG-635807 (SOX4)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001046 core promoter sequence-specific DNA binding
GO:0001071 nucleic acid binding transcription factor activity
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001105 RNA polymerase II transcription coactivator activity
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001501 skeletal system development
GO:0001841 neural tube formation
GO:0002328 pro-B cell differentiation
GO:0003183 mitral valve morphogenesis
GO:0003211 cardiac ventricle formation
GO:0003215 cardiac right ventricle morphogenesis
GO:0003289 atrial septum primum morphogenesis
GO:0003357 noradrenergic neuron differentiation
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007507 heart development
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0014009 glial cell proliferation
GO:0021510 spinal cord development
GO:0021522 spinal cord motor neuron differentiation
GO:0021782 glial cell development
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030217 T cell differentiation
GO:0031018 endocrine pancreas development
GO:0031397 negative regulation of protein ubiquitination
GO:0031647 regulation of protein stability
GO:0032024 positive regulation of insulin secretion
GO:0035019 somatic stem cell maintenance
GO:0035910 ascending aorta morphogenesis
GO:0042593 glucose homeostasis
GO:0042769 DNA damage response, detection of DNA damage
GO:0043065 positive regulation of apoptotic process
GO:0045727 positive regulation of translation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046826 negative regulation of protein export from nucleus
GO:0048485 sympathetic nervous system development
GO:0050821 protein stabilization
GO:0060070 canonical Wnt signaling pathway
GO:0060174 limb bud formation
GO:0060412 ventricular septum morphogenesis
GO:0060548 negative regulation of cell death
GO:0060563 neuroepithelial cell differentiation
GO:0060993 kidney morphogenesis
GO:0071333 cellular response to glucose stimulus
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:2000761 positive regulation of N-terminal peptidyl-lysine acetylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0044798 nuclear transcription factor complex
Protein Structure and Domains
PDB ID
InterPro IPR009071 High mobility group box domain
IPR017386 Transcription factor SOX-12/11/4a
PFAM PF00505
PF09011
PRINTS
PIRSF PIRSF038098
SMART SM00398
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL G3MYL8
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq
HUGO HGNC:11200
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02055577 DAAA02055578
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca