Version 5.4
| Bos taurus Protein: PTN | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||
| InnateDB Protein | IDBP-687676.2 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | PTN | ||||||||
| Protein Name | Pleiotrophin | ||||||||
| Synonyms | |||||||||
| Species | Bos taurus | ||||||||
| Ensembl Protein | ENSBTAP00000002983 | ||||||||
| InnateDB Gene | IDBG-635808 (PTN) | ||||||||
| Protein Structure |
|
||||||||
| UniProt Annotation | |||||||||
| Function | Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti- apoptotic signaling of PTN and regulation of cell proliferation (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Secreted. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 92 interaction(s) predicted by orthology.
|
||||||||
| Gene Ontology | |||||||||
Molecular Function |
|
||||||||
| Biological Process |
|
||||||||
| Cellular Component |
|
||||||||
| Protein Structure and Domains | |||||||||
| PDB ID | |||||||||
| InterPro |
IPR000762
Midkine heparin-binding growth factor IPR020089 Pleiotrophin/Midkine, N-terminal domain IPR020090 Pleiotrophin/Midkine, C-terminal domain IPR020091 Pleiotrophin/Midkine disulphide-rich domain |
||||||||
| PFAM |
PF05196
PF01091 |
||||||||
| PRINTS |
PR00269
|
||||||||
| PIRSF | |||||||||
| SMART |
SM00193
|
||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | P21782 | ||||||||
| PhosphoSite | PhosphoSite- | ||||||||
| TrEMBL | Q9TRV5 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 280904 | ||||||||
| UniGene | Bt.4844 | ||||||||
| RefSeq | NP_776380 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | BC102712 X52945 | ||||||||
| GenPept | AAI02713 CAA37120 | ||||||||