Version 5.4
Bos taurus Protein: PTGES3
Summary
InnateDB Protein IDBP-687757.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTGES3
Protein Name Prostaglandin E synthase 3
Synonyms CPGES;
Species Bos taurus
Ensembl Protein ENSBTAP00000023908
InnateDB Gene IDBG-635887 (PTGES3)
Protein Structure
UniProt Annotation
Function Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor- mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Detected in testis and ovary, at lower levels in endometrium, myometrium, kidney and lung, and only faintly in spleen, heart and muscle (at protein level). Expressed at high levels in glandular and luminal epithelial cells of the endometrium, but also detected in stromal cells (at protein level). {ECO:0000269PubMed:15744024}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 49 interaction(s) predicted by orthology.
Predicted by orthology
Total 49 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016853 isomerase activity
GO:0050220 prostaglandin-E synthase activity
Biological Process
GO:0001516 prostaglandin biosynthetic process
GO:0005978 glycogen biosynthetic process
GO:0006629 lipid metabolic process
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006693 prostaglandin metabolic process
GO:0008283 cell proliferation
GO:0042921 glucocorticoid receptor signaling pathway
GO:0043588 skin development
GO:0060430 lung saccule development
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR007052 CS domain
IPR008978 HSP20-like chaperone
PFAM PF04969
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3ZBF7
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 493638
UniGene Bt.49581
RefSeq NP_001007807
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY692440 BC103350
GenPept AAI03351 AAU04847

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca