InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: NUDT14

Summary

InnateDB Protein

IDBP-687801.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NUDT14

Protein Name

Uridine diphosphate glucose pyrophosphatase

Synonyms

UGPP;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000055697

InnateDB Gene

IDBG-635922 (NUDT14)

Protein Structure

UniProt Annotation

Function

Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP- mannose (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008768	UDP-sugar diphosphatase activity
GO:0016787	hydrolase activity
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0046872	metal ion binding
GO:0047631	ADP-ribose diphosphatase activity

Biological Process

GO:0008152

metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000086 NUDIX hydrolase domain
IPR004385 Nucleoside diphosphate pyrophosphatase
IPR015797 NUDIX hydrolase domain-like

PFAM

PF00293

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q05B60

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

100126049

UniGene

Bt.97205

RefSeq

NP_001099122

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC122769

GenPept

AAI22770