InnateDB Protein
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IDBP-687807.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PSENEN
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Protein Name
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Gamma-secretase subunit PEN-2
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Synonyms
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PEN2;
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000024745
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InnateDB Gene
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IDBG-635931 (PSENEN)
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Protein Structure
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Function |
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity (By similarity). {ECO:0000250}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Predominantly located in the endoplasmic reticulum and in the cis-Golgi. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
12 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR019379
Gamma-secretase aspartyl protease complex, presenilin enhancer-2 subunit
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PFAM |
PF10251
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q5G235
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
493993
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UniGene |
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RefSeq |
NP_001008669
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AY821679
AY863214
BC102375
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GenPept |
AAI02376
AAV84001
AAW65540
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