InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SLX4

Summary

InnateDB Protein

IDBP-687911.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLX4

Protein Name

SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)

Synonyms

BTBD12;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000005923

InnateDB Gene

IDBG-636021 (SLX4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008047	enzyme activator activity
GO:0008821	crossover junction endodeoxyribonuclease activity
GO:0017108	5'-flap endonuclease activity
GO:0048257	3'-flap endonuclease activity

Biological Process

GO:0000724	double-strand break repair via homologous recombination
GO:0000737	DNA catabolic process, endonucleolytic
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006289	nucleotide-excision repair
GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing
GO:0043085	positive regulation of catalytic activity
GO:0072429	response to intra-S DNA damage checkpoint signaling

Cellular Component

GO:0000784	nuclear chromosome, telomeric region
GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0030054	cell junction
GO:0033557	Slx1-Slx4 complex
GO:0048476	Holliday junction resolvase complex
GO:0070522	ERCC4-ERCC1 complex

Protein Structure and Domains

PDB ID

InterPro

IPR000210 BTB/POZ-like
IPR011333 BTB/POZ fold
IPR013069 BTB/POZ

PFAM

PF00651

PRINTS

PIRSF

SMART

SM00225

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

F1N7Q0

UniProt Splice Variant

Entrez Gene

512193

UniGene

Bt.20047

RefSeq

XP_002697931

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02057328 GJ062847

GenPept

DAA15665