InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: HCST

Summary

InnateDB Protein

IDBP-687937.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HCST

Protein Name

Hematopoietic cell signal transducer

Synonyms

DAP10;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000009651

InnateDB Gene

IDBG-636047 (HCST)

Protein Structure

UniProt Annotation

Function

Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells. In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR-induced signals. KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells; indeed, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000269PubMed:17530242}; Single-pass type I membrane protein {ECO:0000269PubMed:17530242}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0043548	phosphatidylinositol 3-kinase binding

Biological Process

GO:0014068

positive regulation of phosphatidylinositol 3-kinase signaling

Cellular Component

GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR009861 DAP10 membrane

PFAM

PF07213

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q1XF11

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

767892

UniGene

RefSeq

NP_001070445

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AM075813 BC142038

GenPept

AAI42039 CAJ27508