Version 5.4
Bos taurus Protein: DPH5
Summary
InnateDB Protein IDBP-687979.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DPH5
Protein Name Diphthine synthase
Synonyms CGI-30;
Species Bos taurus
Ensembl Protein ENSBTAP00000025327
InnateDB Gene IDBG-636086 (DPH5)
Protein Structure
UniProt Annotation
Function S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EEF2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004164 diphthine synthase activity
GO:0008168 methyltransferase activity
GO:0016740 transferase activity
Biological Process
GO:0008152 metabolic process
GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine
GO:0032259 methylation
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR000878 Tetrapyrrole methylase
IPR004551 Diphthine synthase
PFAM PF00590
PRINTS
PIRSF PIRSF036432
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5E982
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 508904
UniGene Bt.63378
RefSeq NP_001070289
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC113310 BT021038
GenPept AAI13311 AAX09055

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca