Version 5.4
Bos taurus Protein: DNASE1
Summary
InnateDB Protein IDBP-687987.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DNASE1
Protein Name Deoxyribonuclease-1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000054758
InnateDB Gene IDBG-636027 (DNASE1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0004530 deoxyribonuclease I activity
GO:0004536 deoxyribonuclease activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters
Biological Process
GO:0000737 DNA catabolic process, endonucleolytic
GO:0006308 DNA catabolic process
GO:0006915 apoptotic process
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR005135 Endonuclease/exonuclease/phosphatase
IPR016202 Deoxyribonuclease I
PFAM PF03372
PF14529
PRINTS PR00130
PIRSF PIRSF000988
SMART SM00476
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL M5FJR2
UniProt Splice Variant
Entrez Gene 282217
UniGene Bt.12952
RefSeq
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF528509 AJ001538 BC142349 DAAA02057328 GJ062847
GenPept AAI42350 AAM93248 CAA04819 DAA15539

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca