InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: DLL1

Summary

InnateDB Protein

IDBP-688027.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DLL1

Protein Name

delta-like 1 (Drosophila)

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000042093

InnateDB Gene

IDBG-636101 (DLL1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005112	Notch binding
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0001756	somitogenesis
GO:0001757	somite specification
GO:0001947	heart looping
GO:0007154	cell communication
GO:0007219	Notch signaling pathway
GO:0007267	cell-cell signaling
GO:0007275	multicellular organismal development
GO:0007368	determination of left/right symmetry
GO:0007386	compartment pattern specification
GO:0032693	negative regulation of interleukin-10 production
GO:0045596	negative regulation of cell differentiation
GO:0045608	negative regulation of auditory receptor cell differentiation
GO:0045638	negative regulation of myeloid cell differentiation
GO:0045665	negative regulation of neuron differentiation
GO:0045747	positive regulation of Notch signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048839	inner ear development
GO:0050767	regulation of neurogenesis
GO:0070986	left/right axis specification
GO:0072014	proximal tubule development
GO:0072070	loop of Henle development
GO:0097150	neuronal stem cell maintenance

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031410	cytoplasmic vesicle

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001774 Delta/Serrate/lag-2 (DSL) protein
IPR001881 EGF-like calcium-binding domain
IPR011651 Notch ligand, N-terminal
IPR013111 EGF-like domain, extracellular

PFAM

PF00008
PF01414
PF07645
PF07657
PF07974

PRINTS

PIRSF

SMART

SM00181
SM00051
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite