InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: HNRNPK

Summary

InnateDB Protein

IDBP-688034.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HNRNPK

Protein Name

Heterogeneous nuclear ribonucleoprotein K

Synonyms

HNRPK;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000028162

InnateDB Gene

IDBG-636114 (HNRNPK)

Protein Structure

UniProt Annotation

Function

One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single- stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non- coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Cell projection, podosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 161 interaction(s) predicted by orthology.

Predicted by orthology
Total	161 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0010988	regulation of low-density lipoprotein particle clearance
GO:0045716	positive regulation of low-density lipoprotein particle receptor biosynthetic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048260	positive regulation of receptor-mediated endocytosis
GO:0072369	regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
GO:1902165	regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

Cellular Component

GO:0000790	nuclear chromatin
GO:0002102	podosome
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005681	spliceosomal complex
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0030054	cell junction
GO:0030529	ribonucleoprotein complex
GO:0042995	cell projection
GO:0070062	extracellular vesicular exosome
GO:0071013	catalytic step 2 spliceosome

Protein Structure and Domains

PDB ID

InterPro

IPR004087 K Homology domain
IPR004088 K Homology domain, type 1
IPR012987 ROK, N-terminal

PFAM

PF00013
PF13014
PF08067

PRINTS

PIRSF

SMART

SM00322

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3T0D0

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

528135

UniGene

Bt.69550

RefSeq

NP_001029734

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC102450

GenPept

AAI02451