Version 5.4
| Bos taurus Protein: DBT | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-688099.2 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | DBT | ||||||||
| Protein Name | Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial | ||||||||
| Synonyms | BCKAD-E2; BCKADE2; E2; E2b; | ||||||||
| Species | Bos taurus | ||||||||
| Ensembl Protein | ENSBTAP00000008292 | ||||||||
| InnateDB Gene | IDBG-636196 (DBT) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component. {ECO:0000269PubMed:283398}. | ||||||||
| Subcellular Localization | Mitochondrion matrix {ECO:0000269PubMed:283398}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Expressed in kidney (at protein level). {ECO:0000269PubMed:283398}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | |||||||||
| InterPro |
IPR000089
Biotin/lipoyl attachment IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain IPR004167 E3 binding IPR011053 Single hybrid motif |
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| PFAM |
PF00364
PF00198 PF02817 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART | |||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | P11181 | ||||||||
| PhosphoSite | PhosphoSite- | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 280759 | ||||||||
| UniGene | Bt.107201 | ||||||||
| RefSeq | NP_776330 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | BC134527 M19475 M21572 | ||||||||
| GenPept | AAA30596 AAA30597 AAI34528 | ||||||||