InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: DNAJC24

Summary

InnateDB Protein

IDBP-688100.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DNAJC24

Protein Name

DnaJ homolog subfamily C member 24

Synonyms

DPH4; ZCSL3;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000000600

InnateDB Gene

IDBG-636190 (DNAJC24)

Protein Structure

UniProt Annotation

Function

Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron- bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001671	ATPase activator activity
GO:0008198	ferrous iron binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0017183	peptidyl-diphthamide biosynthetic process from peptidyl-histidine
GO:0032781	positive regulation of ATPase activity
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton

Protein Structure and Domains

PDB ID

InterPro

IPR001623 DnaJ domain
IPR007872 Zinc finger, DPH-type

PFAM

PF00226
PF05207

PRINTS

PR00625

PIRSF

SMART

SM00271

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q0VBY7

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

768227

UniGene

Bt.103983

RefSeq

NP_001071570

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC120442

GenPept

AAI20443