InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CAPNS1

Summary

InnateDB Protein

IDBP-688146.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CAPNS1

Protein Name

Calpain small subunit 1

Synonyms

CAPN4;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000019803

InnateDB Gene

IDBG-636235 (CAPNS1)

Protein Structure

UniProt Annotation

Function

Regulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Translocates to the plasma membrane upon calcium binding. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004198	calcium-dependent cysteine-type endopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006508

proteolysis

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002048 EF-hand domain

PFAM

PF00036
PF13202
PF13405

PRINTS

PIRSF

SMART

SM00054

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P13135

PhosphoSite

PhosphoSite-

TrEMBL

A0FJZ6

UniProt Splice Variant

Entrez Gene

281664

UniGene

Bt.7181

RefSeq

NP_776686

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC116060 EF015888 EF139087 J05065

GenPept

AAA30422 AAI16061 ABK20177 ABL75413