Version 5.4
Bos taurus Protein: SLC35A3
Summary
InnateDB Protein IDBP-688150.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC35A3
Protein Name UDP-N-acetylglucosamine transporter
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000016519
InnateDB Gene IDBG-636237 (SLC35A3)
Protein Structure
UniProt Annotation
Function Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter in the Golgi apparatus. May supply UDP-GlcNAc as substrate for Golgi-resident glycosyltransferases that generate branching of diantennary oligosaccharides (By similarity). {ECO:0000250}.
Subcellular Localization Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations Note=Defects in SLC35A3 may be cause of complex vertebral malformation (CVM) in Holstein. {ECO:0000269PubMed:16344554}.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005338 nucleotide-sugar transmembrane transporter activity
GO:0005351 sugar:proton symporter activity
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0008643 carbohydrate transport
GO:0015780 nucleotide-sugar transport
GO:0015788 UDP-N-acetylglucosamine transport
GO:0015992 proton transport
GO:0055085 transmembrane transport
GO:1901679 nucleotide transmembrane transport
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000620 Drug/metabolite transporter
IPR004689 UDP-galactose transporter
IPR004853 Triose-phosphate transporter domain
IPR007271 Nucleotide-sugar transporter
IPR013657 UAA transporter
IPR021189 UDP/CMP-sugar transporter
PFAM PF00892
PF03151
PF04142
PF08449
PRINTS
PIRSF PIRSF005799
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6YC49
PhosphoSite PhosphoSite-
TrEMBL D9ZZB6
UniProt Splice Variant
Entrez Gene 790270
UniGene Bt.89410
RefSeq NP_001098856
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY160683 BC153220 EF555203 HM183012
GenPept AAI53221 AAO22138 ABQ45356 ADK26062

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca