InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ERBB3

Summary

InnateDB Protein

IDBP-688238.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ERBB3

Protein Name

receptor tyrosine-protein kinase erbB-3

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000013790

InnateDB Gene

IDBG-636302 (ERBB3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 73 interaction(s) predicted by orthology.

Predicted by orthology
Total	73 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0004716	receptor signaling protein tyrosine kinase activity
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019838	growth factor binding
GO:0030296	protein tyrosine kinase activator activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0003197	endocardial cushion development
GO:0006468	protein phosphorylation
GO:0007162	negative regulation of cell adhesion
GO:0007165	signal transduction
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007422	peripheral nervous system development
GO:0009968	negative regulation of signal transduction
GO:0014037	Schwann cell differentiation
GO:0014065	phosphatidylinositol 3-kinase signaling
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0021545	cranial nerve development
GO:0023014	signal transduction by phosphorylation
GO:0042127	regulation of cell proliferation
GO:0043524	negative regulation of neuron apoptotic process
GO:0051048	negative regulation of secretion
GO:0051402	neuron apoptotic process
GO:0061098	positive regulation of protein tyrosine kinase activity
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005615	extracellular space
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0016328	lateral plasma membrane
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR000494 EGF receptor, L domain
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR006211 Furin-like cysteine-rich domain
IPR006212 Furin-like repeat
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR011009 Protein kinase-like domain
IPR016245 Tyrosine protein kinase, EGF/ERB/XmrK receptor
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF01030
PF00069
PF07714
PF00757

PRINTS

PR00109

PIRSF

PIRSF000619

SMART

SM00220
SM00261
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

A6QR62

UniProt Splice Variant

Entrez Gene

785655

UniGene

Bt.64779

RefSeq

NP_001096575

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC150128 DAAA02013534

GenPept

AAI50129