Version 5.4
Bos taurus Protein: EDA
Summary
InnateDB Protein IDBP-688277.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EDA
Protein Name Ectodysplasin-AEctodysplasin-A, membrane formEctodysplasin-A, secreted form
Synonyms ED1;
Species Bos taurus
Ensembl Protein ENSBTAP00000016649
InnateDB Gene IDBG-636361 (EDA)
Protein Structure
UniProt Annotation
Function Probably involved in epithelial-mesenchymal signaling. Isoform A1 binds only to the receptor EDAR, while isoform A2 binds exclusively to the receptor XEDAR (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.Ectodysplasin-A, secreted form: Secreted {ECO:0000250}.
Disease Associations Note=Defects in EDA are the cause of anhidrotic ectodermal dysplasia. The disease is characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005164 tumor necrosis factor receptor binding
GO:0005515 protein binding
Biological Process
GO:0001942 hair follicle development
GO:0006955 immune response
GO:0007160 cell-matrix adhesion
GO:0007275 multicellular organismal development
GO:0010467 gene expression
GO:0030154 cell differentiation
GO:0042346 positive regulation of NF-kappaB import into nucleus
GO:0042475 odontogenesis of dentin-containing tooth
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043473 pigmentation
GO:0043588 skin development
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060662 salivary gland cavitation
GO:0060789 hair follicle placode formation
GO:0061153 trachea gland development
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005581 collagen trimer
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0045177 apical part of cell
Protein Structure and Domains
PDB ID
InterPro IPR006052 Tumour necrosis factor domain
IPR008160 Collagen triple helix repeat
IPR008983 Tumour necrosis factor-like domain
PFAM PF00229
PF01391
PRINTS
PIRSF
SMART SM00207
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BEG5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 616179
UniGene Bt.101611
RefSeq NP_001075212
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AJ278907 AJ300468 AJ300469
GenPept CAC29151 CAC29152

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca