Version 5.4
Bos taurus Protein: F3
Summary
InnateDB Protein IDBP-688306.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol F3
Protein Name Tissue factor
Synonyms TF;
Species Bos taurus
Ensembl Protein ENSBTAP00000009341
InnateDB Gene IDBG-636392 (F3)
Protein Structure
UniProt Annotation
Function Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
Subcellular Localization Membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0005515 protein binding
GO:0005543 phospholipid binding
Biological Process
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002541 activation of plasma proteins involved in acute inflammatory response
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0010641 positive regulation of platelet-derived growth factor receptor signaling pathway
GO:0045766 positive regulation of angiogenesis
GO:0051897 positive regulation of protein kinase B signaling
Cellular Component
GO:0005615 extracellular space
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001187 Tissue factor
IPR003961 Fibronectin, type III
IPR015373 Interferon alpha/beta receptor, beta chain
IPR016354 Tissue factor/coagulation factor III
PFAM PF00041
PF01108
PF09294
PRINTS PR00346
PIRSF PIRSF002498
SMART SM00060
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P30931
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 280686
UniGene Bt.4106
RefSeq NP_776303
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC123808 S74147
GenPept AAB20755 AAI23809

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca