Version 5.4
Bos taurus Protein: PLCB1
Summary
InnateDB Protein IDBP-688315.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLCB1
Protein Name 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000046644
InnateDB Gene IDBG-636390 (PLCB1)
Protein Structure
UniProt Annotation
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Subcellular Localization Nucleus membrane {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004871 signal transducer activity
GO:0005096 GTPase activator activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005521 lamin binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0008081 phosphoric diester hydrolase activity
GO:0016787 hydrolase activity
GO:0019899 enzyme binding
Biological Process
GO:0006629 lipid metabolic process
GO:0007165 signal transduction
GO:0007213 G-protein coupled acetylcholine receptor signaling pathway
GO:0007215 glutamate receptor signaling pathway
GO:0007420 brain development
GO:0007613 memory
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0016042 lipid catabolic process
GO:0021987 cerebral cortex development
GO:0032735 positive regulation of interleukin-12 production
GO:0035556 intracellular signal transduction
GO:0035722 interleukin-12-mediated signaling pathway
GO:0035723 interleukin-15-mediated signaling pathway
GO:0040019 positive regulation of embryonic development
GO:0043547 positive regulation of GTPase activity
GO:0045444 fat cell differentiation
GO:0045663 positive regulation of myoblast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046330 positive regulation of JNK cascade
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0048639 positive regulation of developmental growth
GO:0051726 regulation of cell cycle
GO:0060466 activation of meiosis involved in egg activation
GO:0070498 interleukin-1-mediated signaling pathway
GO:0080154 regulation of fertilization
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:2000344 positive regulation of acrosome reaction
GO:2000438 negative regulation of monocyte extravasation
GO:2000560 positive regulation of CD24 biosynthetic process
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0016607 nuclear speck
GO:0031965 nuclear membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000008 C2 domain
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001192 Phosphoinositide phospholipase C family
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR009535 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta, conserved site
IPR014815 PLC-beta, C-terminal
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR016280 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
PFAM PF00168
PF00388
PF00387
PF06631
PF08703
PF09279
PRINTS PR00360
PR00390
PIRSF PIRSF000956
SMART SM00239
SM00148
SM00149
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P10894
PhosphoSite PhosphoSite-P10894
TrEMBL
UniProt Splice Variant
Entrez Gene 287026
UniGene Bt.448
RefSeq NP_777242
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL J03137
GenPept AAA30702

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca