InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: BRE

Summary

InnateDB Protein

IDBP-688354.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BRE

Protein Name

BRCA1-A complex subunit BRE

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000041902

InnateDB Gene

IDBG-636423 (BRE)

Protein Structure

UniProt Annotation

Function

Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Localizes at sites of DNA damage at double- strand breaks (DSBs). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.

Predicted by orthology
Total	39 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding
GO:0031593	polyubiquitin binding

Biological Process

GO:0006281	DNA repair
GO:0006302	double-strand break repair
GO:0006915	apoptotic process
GO:0006974	cellular response to DNA damage stimulus
GO:0010212	response to ionizing radiation
GO:0016568	chromatin modification
GO:0031572	G2 DNA damage checkpoint
GO:0045739	positive regulation of DNA repair

Cellular Component

GO:0000152	nuclear ubiquitin ligase complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0070531	BRCA1-A complex
GO:0070552	BRISC complex

Protein Structure and Domains

PDB ID

InterPro

IPR010358 Brain/reproductive organ-expressed protein
IPR016135 Ubiquitin-conjugating enzyme/RWD-like

PFAM

PF06113

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A6QQW8

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

614152

UniGene

Bt.4351

RefSeq

NP_001095744

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC150022

GenPept

AAI50023