InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: GCLM

Summary

InnateDB Protein

IDBP-688355.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GCLM

Protein Name

Glutamate--cysteine ligase regulatory subunit

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000026855

InnateDB Gene

IDBG-636430 (GCLM)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004357	glutamate-cysteine ligase activity
GO:0035226	glutamate-cysteine ligase catalytic subunit binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006534	cysteine metabolic process
GO:0006536	glutamate metabolic process
GO:0006749	glutathione metabolic process
GO:0006750	glutathione biosynthetic process
GO:0006979	response to oxidative stress
GO:0008637	apoptotic mitochondrial changes
GO:0035229	positive regulation of glutamate-cysteine ligase activity
GO:0042493	response to drug
GO:0050880	regulation of blood vessel size
GO:0051900	regulation of mitochondrial depolarization
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0017109

glutamate-cysteine ligase complex

Protein Structure and Domains

PDB ID

InterPro

IPR023210 NADP-dependent oxidoreductase domain

PFAM

PF00248

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q2T9Y6

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

525659

UniGene

Bt.20267

RefSeq

NP_001033232

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC111206

GenPept

AAI11207