Version 5.4
Bos taurus Protein: FBP1
Summary
InnateDB Protein IDBP-688386.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBP1
Protein Name Fructose-1,6-bisphosphatase 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000012835
InnateDB Gene IDBG-636464 (FBP1)
Protein Structure
UniProt Annotation
Function Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0016208 AMP binding
GO:0016787 hydrolase activity
GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity
GO:0042578 phosphoric ester hydrolase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0048029 monosaccharide binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006002 fructose 6-phosphate metabolic process
GO:0006094 gluconeogenesis
GO:0006111 regulation of gluconeogenesis
GO:0008152 metabolic process
GO:0016311 dephosphorylation
GO:0030308 negative regulation of cell growth
GO:0035690 cellular response to drug
GO:0045820 negative regulation of glycolytic process
GO:0046580 negative regulation of Ras protein signal transduction
GO:0046854 phosphatidylinositol phosphorylation
GO:0051289 protein homotetramerization
GO:0071286 cellular response to magnesium ion
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000146 Fructose-1,6-bisphosphatase class 1/Sedoheputulose-1,7-bisphosphatase
IPR000760 Inositol monophosphatase
IPR023079 Sedoheptulose-1,7-bisphosphatase
IPR028343 Fructose-1,6-bisphosphatase
PFAM PF00316
PF00459
PRINTS PR00377
PR01958
PR00115
PIRSF PIRSF000904
PIRSF500210
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3SZB7
PhosphoSite PhosphoSite-
TrEMBL B3RFM8
UniProt Splice Variant
Entrez Gene 513483
UniGene
RefSeq NP_001029619
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102974 DQ166528
GenPept AAI02975 AAZ99065

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca