Version 5.4
Bos taurus Protein: TCN2
Summary
InnateDB Protein IDBP-688426.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TCN2
Protein Name Transcobalamin-2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000029446
InnateDB Gene IDBG-636501 (TCN2)
Protein Structure
UniProt Annotation
Function Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Expressed in mammary gland, kidney, lymphatic nodes and liver.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0031419 cobalamin binding
GO:0046872 metal ion binding
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006824 cobalt ion transport
GO:0009235 cobalamin metabolic process
GO:0015889 cobalamin transport
Cellular Component
GO:0005576 extracellular region
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002157 Cobalamin (vitamin B12)-binding transporter, eukaryotic
PFAM PF01122
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9XSC9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281518
UniGene Bt.44412
RefSeq NP_776620
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF121289 BC114678 BT021579 BT021659 BT021880 BT021899 BT026178 BT026282
GenPept AAD23829 AAI14679 AAX46426 AAX46506 AAX46727 AAX46746 ABG67017 ABG81438

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca