Version 5.4
Bos taurus Protein: NAGPA
Summary
InnateDB Protein IDBP-688429.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NAGPA
Protein Name N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000010385
InnateDB Gene IDBG-636503 (NAGPA)
Protein Structure
UniProt Annotation
Function Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P- mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N- acetylglucosaminyltransferases.
Subcellular Localization Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network {ECO:0000250}. Note=Cis/medial Golgi. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003944 N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006486 protein glycosylation
Cellular Component
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0032580 Golgi cisterna membrane
Protein Structure and Domains
PDB ID
InterPro IPR018711 Domain of unknown function DUF2233
PFAM PF09992
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P68827
PhosphoSite PhosphoSite-
TrEMBL G5E597
UniProt Splice Variant
Entrez Gene 515935
UniGene
RefSeq XP_005224507
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02057357 GJ062847
GenPept DAA15726

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca