Version 5.4
Bos taurus Protein: CAT
Summary
InnateDB Protein IDBP-688448.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CAT
Protein Name Catalase
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000027941
InnateDB Gene IDBG-636518 (CAT)
Protein Structure
UniProt Annotation
Function Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.
Subcellular Localization Peroxisome.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004046 aminoacylase activity
GO:0004096 catalase activity
GO:0004601 peroxidase activity
GO:0005102 receptor binding
GO:0016209 antioxidant activity
GO:0016491 oxidoreductase activity
GO:0016684 oxidoreductase activity, acting on peroxide as acceptor
GO:0019899 enzyme binding
GO:0020037 heme binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0050661 NADP binding
Biological Process
GO:0000302 response to reactive oxygen species
GO:0001649 osteoblast differentiation
GO:0006641 triglyceride metabolic process
GO:0006979 response to oxidative stress
GO:0008203 cholesterol metabolic process
GO:0009060 aerobic respiration
GO:0009650 UV protection
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0020027 hemoglobin metabolic process
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0042744 hydrogen peroxide catabolic process
GO:0043066 negative regulation of apoptotic process
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051262 protein tetramerization
GO:0051289 protein homotetramerization
GO:0051781 positive regulation of cell division
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR010582 Catalase immune-responsive domain
IPR011614 Catalase core domain
IPR018028 Catalase, mono-functional, haem-containing
IPR020835 Catalase-like domain
PFAM PF06628
PF00199
PRINTS PR00067
PIRSF
SMART SM01060
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P00432
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 531682
UniGene Bt.97410
RefSeq NP_001030463
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC103066
GenPept AAI03067

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca