Version 5.4
Bos taurus Protein: RPAP2
Summary
InnateDB Protein IDBP-688514.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPAP2
Protein Name RNA polymerase II associated protein 2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000041791
InnateDB Gene IDBG-636582 (RPAP2)
Protein Structure
UniProt Annotation
Function Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Shuttles between the cytoplasm and the nucleus in a CRM1-dependent manner. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.
Predicted by orthology
Total 43 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0008420 CTD phosphatase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0009301 snRNA transcription
GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016591 DNA-directed RNA polymerase II, holoenzyme
Protein Structure and Domains
PDB ID
InterPro IPR007308 Protein of unknown function DUF408
PFAM PF04181
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt F6RRD7
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 529184
UniGene Bt.29255
RefSeq NP_001096736
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC123867 DAAA02007907
GenPept AAI23868

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca