InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: LTA4H

Summary

InnateDB Protein

IDBP-688565.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LTA4H

Protein Name

Leukotriene A-4 hydrolase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000021833

InnateDB Gene

IDBG-636614 (LTA4H)

Protein Structure

UniProt Annotation

Function

Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004177	aminopeptidase activity
GO:0004301	epoxide hydrolase activity
GO:0004463	leukotriene-A4 hydrolase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006508	proteolysis
GO:0019370	leukotriene biosynthetic process
GO:0043171	peptide catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR012777 Leukotriene A4 hydrolase
IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal
IPR015211 Peptidase M1, leukotriene A4 hydrolase, aminopeptidase C-terminal
IPR016024 Armadillo-type fold

PFAM

PF01433
PF09127

PRINTS

PR00756

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3SZH7