InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SNX17

Summary

InnateDB Protein

IDBP-688604.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNX17

Protein Name

Sorting nexin-17

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000025998

InnateDB Gene

IDBG-636654 (SNX17)

Protein Structure

UniProt Annotation

Function

Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Early endosome {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008289	lipid binding
GO:0035091	phosphatidylinositol binding
GO:0050750	low-density lipoprotein particle receptor binding

Biological Process

GO:0006810	transport
GO:0006898	receptor-mediated endocytosis
GO:0007165	signal transduction
GO:0015031	protein transport

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005769	early endosome
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030659	cytoplasmic vesicle membrane
GO:0031410	cytoplasmic vesicle
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR000159 Ras-association
IPR001683 Phox homologous domain
IPR019748 FERM central domain
IPR029071 Ubiquitin-related domain

PFAM

PF00788
PF00787
PF00373

PRINTS

PIRSF

SMART

SM00314
SM00312

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5EA77

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

529972

UniGene

Bt.97079

RefSeq

NP_001015638

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC118249 BT020692

GenPept

AAI18250 AAX08709