Version 5.4
Bos taurus Protein: CD44
Summary
InnateDB Protein IDBP-688637.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD44
Protein Name CD44 antigen
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000048925
InnateDB Gene IDBG-636564 (CD44)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.
Predicted by orthology
Total 48 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004415 hyalurononglucosaminidase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0005540 hyaluronic acid binding
Biological Process
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0002246 wound healing involved in inflammatory response
GO:0007155 cell adhesion
GO:0010628 positive regulation of gene expression
GO:0016055 Wnt signaling pathway
GO:0030214 hyaluronan catabolic process
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034116 positive regulation of heterotypic cell-cell adhesion
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051216 cartilage development
GO:0060442 branching involved in prostate gland morphogenesis
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070487 monocyte aggregation
GO:1900625 positive regulation of monocyte aggregation
GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000538 Link
IPR001231 CD44 antigen
IPR016187 C-type lectin fold
PFAM PF00193
PRINTS PR01265
PR00658
PIRSF
SMART SM00445
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F1MQT9
UniProt Splice Variant
Entrez Gene 281057
UniGene Bt.5494
RefSeq
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02041295 DAAA02041296 EU041904
GenPept ABW75070

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca