Version 5.4
Bos taurus Protein: SEC61A2
Summary
InnateDB Protein IDBP-688712.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEC61A2
Protein Name Protein transport protein Sec61 subunit alpha isoform 2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000025985
InnateDB Gene IDBG-636753 (SEC61A2)
Protein Structure
UniProt Annotation
Function Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0043022 ribosome binding
Biological Process
GO:0006810 transport
GO:0015031 protein transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR002208 SecY/SEC61-alpha family
IPR019561 Translocon Sec61/SecY, plug domain
PFAM PF00344
PF10559
PRINTS
PIRSF PIRSF004557
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2KHX4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 614128
UniGene Bt.59559
RefSeq NP_001039989
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC112848
GenPept AAI12849

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca