InnateDB Protein
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IDBP-688723.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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UXT
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Protein Name
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Protein UXT
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000030041
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InnateDB Gene
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IDBG-636768 (UXT)
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Protein Structure
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Function |
Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor (AR) transcription. AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation. Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling. Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC. May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function. Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM. Together with URI1, associates with chromatin to the NKX3-1 promoter region (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
18 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003994
Prefoldin-related, ubiquitously expressed transcript
IPR004127
Prefoldin alpha-like
IPR009053
Prefoldin
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PFAM |
PF02996
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PRINTS |
PR01502
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q32P97
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
525680
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UniGene |
Bt.62980
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RefSeq |
NP_001032548
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC108205
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GenPept |
AAI08206
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