InnateDB Protein
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IDBP-688864.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ATP5C1
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Protein Name
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ATP synthase subunit gamma, mitochondrial
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000018505
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InnateDB Gene
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IDBG-636884 (ATP5C1)
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Protein Structure
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Function |
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
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Subcellular Localization |
Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
39 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000131
ATPase, F1 complex, gamma subunit
IPR023633
ATPase, F1 complex, gamma subunit domain
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PFAM |
PF00231
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PRINTS |
PR00126
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P05631
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PhosphoSite |
PhosphoSite-P05631
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
783991
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UniGene |
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RefSeq |
NP_001068604
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC102466
M22463
X55389
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GenPept |
AAA30398
AAI02467
CAA39064
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