InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PQBP1

Summary

InnateDB Protein

IDBP-688910.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PQBP1

Protein Name

Polyglutamine-binding protein 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000024621

InnateDB Gene

IDBG-636936 (PQBP1)

Protein Structure

UniProt Annotation

Function

Probably functions as scaffold protein that is part of numerous complexes and thereby plays a role in pre-mRNA splicing, transcription regulation and neuron development. Required for normal alternative splicing of target pre-mRNA species. May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Nucleus speckle {ECO:0000250}. Note=Colocalized with ATXN1 in nuclear inclusion bodies. Colocalized with POU3F2. Colocalizes with SRSF2 in nuclear speckles (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0043021	ribonucleoprotein complex binding

Biological Process

GO:0000380	alternative mRNA splicing, via spliceosome
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0031175	neuron projection development
GO:0034063	stress granule assembly
GO:0043484	regulation of RNA splicing
GO:0048814	regulation of dendrite morphogenesis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0010494	cytoplasmic stress granule
GO:0016607	nuclear speck
GO:0071598	neuronal ribonucleoprotein granule

Protein Structure and Domains

PDB ID

InterPro

IPR001202 WW domain

PFAM

PF00397

PRINTS

PIRSF

SMART

SM00456

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q2HJC9

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

534894

UniGene

Bt.13598

RefSeq

NP_001039854

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC105573

GenPept

AAI05574