InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: TNP2

Summary

InnateDB Protein

IDBP-688934.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNP2

Protein Name

Nuclear transition protein 2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000048966

InnateDB Gene

IDBG-636956 (TNP2)

Protein Structure

UniProt Annotation

Function

In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins.

Subcellular Localization

Nucleus. Chromosome.

Disease Associations

Tissue Specificity

Testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0007339	binding of sperm to zona pellucida
GO:0007340	acrosome reaction
GO:0007341	penetration of zona pellucida
GO:0030154	cell differentiation
GO:0030317	sperm motility

Cellular Component

GO:0000786	nucleosome
GO:0005634	nucleus
GO:0005694	chromosome

Protein Structure and Domains

PDB ID

InterPro

IPR000678 Nuclear transition protein 2

PFAM

PF01254

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC109800 BK006514 GJ062847 X56400 X56401

GenPept

AAI09801 CAA39810 CAA39811 DAA06276 DAA15537

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca