Version 5.4
Bos taurus Protein: UBE2D1
Summary
InnateDB Protein IDBP-688966.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBE2D1
Protein Name Ubiquitin-conjugating enzyme E2 D1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000051358
InnateDB Gene IDBG-636987 (UBE2D1)
Protein Structure
UniProt Annotation
Function Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4 (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 228 interaction(s) predicted by orthology.
Predicted by orthology
Total 228 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0016881 acid-amino acid ligase activity
Biological Process
GO:0000209 protein polyubiquitination
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
GO:0031398 positive regulation of protein ubiquitination
GO:0070936 protein K48-linked ubiquitination
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005737 cytoplasm
GO:0043234 protein complex
Protein Structure and Domains
PDB ID
InterPro IPR000608 Ubiquitin-conjugating enzyme, E2
IPR016135 Ubiquitin-conjugating enzyme/RWD-like
PFAM PF00179
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2TA10
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 535287
UniGene Bt.52062
RefSeq NP_001033256
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC111175
GenPept AAI11176

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca